ABSTRACT
Cognitive dysfunction is one of the manifestations of the neurological complications in coronavirus infection. In this article, we have collected material on the state of cognitive functions after suffering a coronavirus infection with aspects of possible pathogenetic mechanisms and a discussion on the prospects for treatment and rehabilitation. The COVID-19 pandemic, having manifested itself in December 2019, remains one of the most controversial topics in the world to the day. The growing number of reports about damage to the nervous system during coronavirus infection suggests that the virus is neurotropic. In the clinical picture of the disease, less attention is paid to such symptoms as severe weakness, fatigue, memory impairment. At the same time, it is this symptomatology that most often accompanies patients in the postcovid period and significantly reduces their quality of life, thereby making it difficult to adapt to social and work activities. The search was conducted for literatures published within the period from 2020 to the third quarter of 2021, domestic and foreign sources from the Web of Science, PubMed databases were analysed. The search queries were the following ones: "COVID-19", "cognitive impairment", "postcovid syndrome".Copyright © 2022, Krasnoyarsk State Medical University. All rights reserved.
ABSTRACT
OBJECTIVE: To assess the state of cognitive functions in patients in the acute period of coronavirus infection with pneumonia during periods of hospitalization in 2020-2022. MATERIAL AND METHODS: The study included 3 groups of people of different ages. The first and second groups are inpatients in the acute period of coronavirus infection with viral pneumonia during treatment in a hospital in Krasnoyarsk. Group 1 was hospitalized in the period December 2020 - March 2021. The second group was hospitalized in the period November 2021 - January 2022. The control group consisted of clinically healthy individuals. MMSE, MoCA, FAB, CDT were used to assess the neuropsychological status. Anxiety and depression were assessed using HADS. Patients in the groups were tested on the first day after stabilization of the condition, then again for discharge or transfer to another hospital. The control group was tested once. RESULTS: Statically significant cognitive impairments were detected in patients with coronavirus infection with viral pneumonia in the acute period of the disease, both at admission and at discharge, compared with the control group. Patients admitted for the period December 2020 - March 2021 had more pronounced cognitive impairment than patients admitted for the period November 2021 - January 2022. Anxiety and depression were not detected on HADS. CONCLUSION: Coronavirus infection with viral pneumonia causes cognitive impairment in patients in the acute period of the disease. The severity of changes of cognitive functions was different depending on outbreaks of infection, which may probably be due to a mutation of the virus for the period 2020-2022.
Subject(s)
COVID-19 , Cognitive Dysfunction , Pneumonia, Viral , Humans , COVID-19/complications , Pneumonia, Viral/epidemiology , Pneumonia, Viral/therapy , Cognition , Cognitive Dysfunction/etiology , Disease OutbreaksABSTRACT
Cognitive dysfunction is one of the manifestations of the neurological complications in coronavirus infection. In this article, we have collected material on the state of cognitive functions after suffering a coronavirus infection with aspects of possible pathogenetic mechanisms and a discussion on the prospects for treatment and rehabilitation. The COVID-19 pandemic, having manifested itself in December 2019, remains one of the most controversial topics in the world to the day. The growing number of reports about damage to the nervous system during coronavirus infection suggests that the virus is neurotropic. In the clinical picture of the disease, less attention is paid to such symptoms as severe weakness, fatigue, memory impairment. At the same time, it is this symptomatology that most often accompanies patients in the postcovid period and significantly reduces their quality of life, thereby making it difficult to adapt to social and work activities. The search was conducted for literatures published within the period from 2020 to the third quarter of 2021, domestic and foreign sources from the Web of Science, PubMed databases were analysed. The search queries were the following ones: “COVID-19”, “cognitive impairment”, “postcovid syndrome”. © 2022, Krasnoyarsk State Medical University. All rights reserved.